Classification of the substance or mixture Classification (GHS-US) Not classified 2.2. SYMPTOMS: Large doses of this chemical usually induce vomiting, so acute intoxication by mouth is rare. Lesson Summary. It is odorless and has a saline taste. <2.5 mEq/L or symptomatic hypokalemia (excluding emergency treatment of cardiac arrest): 40 mEq/hr maximum infusion rate (central line only) in presence of continuous ECG monitoring and frequent lab . Pharmaco-genomics. The chief indication for potassium administration is potassium deficiency or hypokalemia, a condition in which serum potassium level falls below a critical range. in adults, over a 2 minute period antagonises the cardiac and neuromuscular effects. Prevention of deficiency Potassium Chloride Side effects CNS- confusion, restlessness, weakness CV-Arrhithmias, ECG changes GI- abdominal pain, diarrhea, flatulence, nausea, vomiting Tablets & capsules only- GI ulceration, stenotic lesions Local- irritation at IV site Neuro- paralysis, paresthesia Care is required as nerve, tendon, and vascular damage has occurred and may require amputation. 58 / Monday, March 26, 2012 / Rules and . Your provider will check your potassium levels (and other labs) on a regular basis to ensure you are on the right dose. You may experience these side effects: Nausea, vomiting, diarrhea (taking the drugs with meals, diluting them further may help). Some drugs may have another patient information leaflet. Its solutions are neutral to litmus. Classification: Electrolyte Supplements Therapeutic class: Potassium supplements Pharmacologic class: Potassium salts Generic Name: Potassium Chloride Expected Pharmacological Action (Pharmacology): Replaces potassium and maintains potassium level. Find patient medical information for potassium chloride in D5-0.45 % sodium chloride intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user . Now, loop diuretics block these transporters, so these ions end up being excreted, and water follows them passively later across the collecting duct. Further dose based on serum potassium levels. The solid dissolves readily in water, and its solutions have a salt-like taste.Potassium chloride can be obtained from ancient dried lake deposits. Previous to this approval, FDA approved another 505 (b) (2) application for the drug on December 22, 2014. Potassium chloride should be diluted in a suitable I.V. Potassium chloride is an inorganic salt, which is easily soluble in water and glycerol, but insoluble in alcohol. have been identified in different types of body cells. 2) Hypertension. 8.3 Pediatric Use . These intravenous solutions are indicated for use in adults and pediatric patients as sources of . Potassium chloride is an ionic compound and is a salt that naturally occurs as a solid that has a powdery and crystalline appearance. Potassium replacement action: Potassium, . Simply touching crystals or pellets will not cause a burn, according to the IPCS and its MSDS, as the compound is in a stable state. Pharmaco-metabolomics. Do not attempt to take action without suitable protective equipment. Potassium chloride (Klor-Con) is used to treat low potassium levels, or to prevent potassium levels from going too low due to certain medical conditions or medications. Potassium is essential for the proper functioning of the heart, kidneys, muscles, nerves, and digestive system. Used as dietary supplements. Follow directions for diluting various liquid forms of KCl exactly. Usual Dose: 16 to 24 mEq of potassium supplement PO daily. Class: Diuretics Pharm. Nursing Women: There are no adequate data from the use of Potassium Chloride Injection in lactating women. Potassium chloride is a potassium salt used to treat hypokalemia . POTASSIUM CHLORIDE AR MSDS CAS No: MSDS SECTION 1: Identification of the substance/mixture and of the company/undertaking . . Learn about the side effects, dosage, and pregnancy safety information for potassium chloride. Download the Davis's Drug Guide app by Unbound Medicine. To be more specific, they mainly target the thick ascending limb, which has sodium-potassium-chloride cotransporters that normally reabsorb 30% of the filtered sodium, potassium, and chloride. Usually the food you eat supplies all of the potassium you need. Name Product identifier % GHS-US classification potassium chloride (CAS No) 7447-40-7 100 Not classified . Report tingling of the hands or feet, unusual tiredness or weakness, feeling of heaviness in the legs, severe nausea, vomiting, abdominal pain, black or tarry stools, pain at IV injection site. Studies with Potassium Chloride in 0.9% Sodium Chloride Injection, USP have not been performed to evaluate carcinogenic potential, mutagenic potential or effects on fertility. These products are intended for intravenous administration. KCl. Potassium chloride is a medication used in the management and treatment of hypokalemia. 2022-05-10 Potassium chloride is an inorganic salt, which is easily soluble in water and glycerol, but insoluble in alcohol. The CAS numbers are Potassium Chloride 7447-40-7 and Sodium Chloride 7647-14-5. As an estimate, 10 mEq of potassium chloride will roughly increase serum levels by 0.1 mEq/L. If no pre-existing kidney damage, it is rapidly excreted. This activity outlines the indications, action, and contraindications for potassium chloride as a valuable agent in the management and treatment of hypokalemia. For example, it is important in nerve conduction, muscle contraction, and kidney function. Drug Reactions. Class: Loop diuretics Indications: 1) Edema due to heart failure, hepatic impairment, or renal disease. The contribution of the ions can be fortuitously estimated as 2 × [Na] (in mmol/L), for three reasons: •. Pathways. Drug Classification. mineral and electrolyte replacements/supplements There's more to see -- the rest of this entry is available only to subscribers. POTASSIUM CHLORIDE (POTASSIUM CHLORIDE) Chemwatch: 10205 Version No: 5.1.1.1 Safety Data Sheet according to WHS and ADG requirements Issue Date: 05/04/2015 Print Date: 12/29/2016 L.GHS.AUS.EN SECTION 1 IDENTIFICATION OF THE SUBSTANCE / MIXTURE AND OF THE COMPANY / UNDERTAKING Product Identifier Product name POTASSIUM CHLORIDE (POTASSIUM CHLORIDE) Barium was used to reduce potassium conductance and replacement of sodium chloride by lithium chloride was used to reduce the sodium-calcium exchange current. Molecular Weight 74.55. In general, dilute each 20 mEq potassium in at least 90 mL water or juice and allowed to completely before administration. Potassium chloride can be given intravenously and orally. Categories. The chemical name of the active ingredient is Potassium Chloride, and the structural formula is KCl. Potassium deficiency occurs when potassium loss exceeds intake. Sodium Bicarbonate. Simplot Potassium Chloride Ice Melt Safety Data Sheet according to Federal Register / Vol. Synonyms: Potassium chloride. Excerpt Potassium chloride is a medication used in the management and treatment of hypokalemia. Multimedia: Slideshows, Images & Quizzes Large doses by mouth can cause gastrointestinal irritation, purging, weakness, and circulatory disturbances. Dilute liquid forms as directed before giving it through nasogastric tube. In general, dilute each 20 mEq potassium in at least 90 mL water or juice and allowed to completely before administration. Hypokalemia (low potassium) or hyperkalemia (high potassium) may result, manifesting as various signs and . In some countries, this medicine may only be approved for veterinary use. This activity outlines the indications, action, and contraindications for potassium chloride as a valuable agent in the management and treatment of hypokalemia. The duration of action is approximately 1 This inhibition results in increased excretion of water along Continuing Education Activity. You should not take potassium phosphate and sodium phosphate if you are allergic to it, or if you have: severe kidney disease; or; high levels of phosphorus in your blood (hyperphosphatemia). Supplemental potassium in the form of high potassium food or potassium chloride . Potassium chloride (KLor Con, K-Tab, Kaon CL, Klorvess, Slow-K, Ten-K, Klotrix, K-Lyte CL) is a supplement used to treat low blood levels of potassium, a condition called hypokalemia. 1. The injection form of this medicine is recommended for use when the patient is not able to tolerate oral supplements. KCl is used as a fertilizer, in medicine, in scientific applications, and . 1272/2008 [CLP] Not classified . Potassium chloride. Dosing based on serum potassium. Potassium plays a role in the transmission of nerve signals, muscle contractions, fluid balance, and various chemical reactions. mediates active reabsorption of sodium chloride in the thick ascending limb of the loop of Henle and is the site of action of the clinically important diuretics furosemide and bumetanide. Potassium maintains intracellular tonicity, is required for nerve conduction, cardiac, skeletal and smooth muscle contraction, production of energy, the synthesis of nucleic acids, maintenance of blood pressure and normal renal function. Potassium chloride (KCl, or potassium salt) is a metal halide salt composed of potassium and chlorine.It is odorless and has a white or colorless vitreous crystal appearance. Open All Potassium chloride Classification Indications Contraindications Adult dosages 10 mEq of KCL increases serum potassium levels approximately 0.1 mEq/L CCP: Hypokalemia Up to 10 mEq/hr IV (max dose of 10 mEq/hr up to 200 mEq/day) If K is < 2 mEq/L with ECG changes and/or muscle paralysis a max dose of 40 mEq/hr up to 400 mEq/day Potassium is most commonly used for treating and preventing low. The electric charge symbols of plus (+) and minus (−) indicate that the substance in question is ionic in nature and has an imbalanced . Classification of straight Nitrogen fertilizer. Chemical structure: KCI and NaCI Description Potassium chloride and sodium chloride occur as colourless or white crystals and are freely soluble in water. (K2SO4.2MgSO4), but it can also be manufactured by the action of sulfuric acid on potassium chloride. The NDC Code 68382-600-01 is assigned to a package of 100 tablet, film coated, extended release in 1 bottle of Potassium Chloride, a human prescription drug labeled by Zydus Pharmaceuticals Usa Inc. Dilute liquid forms as directed before giving it through nasogastric tube. The latter study suggests that NKCC1 becomes inactive and . The normal potassium ion content of human milk is about 13 mEq per liter. Health Hazard. Molecular Weight 74.55. Its chemical formula is KCl: it consists of . Try the app for free! the most common adverse reactions to oral potassium salts are nausea, vomiting, abdominal discomfort and diarrhea. What Are Side Effects Associated with Using Potassium Chloride? Many conditions and diseases interfere with normal body potassium balance, and underconsumption of potassium is one example. Potassium chloride is divided into agricultural grade potassium . POTASSIUM CHLORIDE (oral) General Indications Action Pharmacokinetics Contraindication / Precautions Adverse Reactions / Side Effects Interactions Route / Dosage Availability Assessment Potential Diagnoses Classification of the substance or mixture HAZARDOUS CHEMICAL. The potassium ion is the principal intracellular cation of most body tissues. 58 / Monday, March 26, 2012 / Rules and Regulations . Do not ever give potassium chloride via IV push. Drugs. You can cancel anytime within the 30-day trial, or continue using Davis's Drug Guide to begin a 1-year subscription ($39.95) POTASSIUM CITRATE. It is freely soluble in water and insoluble in alcohol. General drug facts If your symptoms or health problems do not get better or if they become worse, call your doctor. KCl. CAS 7447-40-7. Regulatory Classification Rx Presentation/Packing Form Kalium Durules SR tab 750 mg Packing/Price potassium chloride - Drug Summary CLASSES Alkalinizing Agents Carbohydrate IV Solutions and Additives, more than 10% Electrolytes with Carbohydrate Solutions Potassium Supplements Sodium Chloride Solutions with Potassium Supplemental Dietary Agents DEA CLASS OTC, Rx DESCRIPTION Potassium is primary intracellular cation Potassium levels are not necessarily indicative of tissue potassium levels. The product's dosage form is tablet, extended release and is administered via oral form. Potassium chloride is an ionic salt featuring a bond between an alkali metal and a halogen. 3 . The [Cl −] i is maintained at high level in immature MNs by the sodium-potassium-chloride cotransporter type 1 (NKCC1), as shown by the fact that blocking this transporter hyperpolarizes E Cl in chick embryo (Gonzalez-Islas et al., 2009) and E11-13 mouse MNs (Delpy et al., 2008). Starred Drugs. Sodium Potassium Chloride Cotransporter. Mix the powder form of this medicine with at least 4 ounces (one-half cup) of cold water or fruit juice before taking. Pharmaco-transcriptomics . CAS 7447-40-7. Potassium chloride (KLor Con, K-Tab, Kaon CL, Klorvess, Slow-K, Ten-K, Klotrix, K-Lyte CL) is a supplement used to treat low blood levels of potassium, a condition called hypokalemia. 77, No. Intravenous Potassium chloride is activated when wet. Potassium chloride is a medication used in the management and treatment of hypokalemia. Drug Targets. Potassium is a mineral that your body needs for proper functioning of the heart, muscles, kidneys . Calculation of osmolality. The Baxter Potassium Chloride and Sodium Chloride Intravenous Infusion is a sterile, non-pyrogenic solution. It has the shape of small white or red crystals and large white or red particles. The role of potassium and sodium-calcium exchange currents on action potential duration was therefore investigated in Purkinje fibres surviving infarction and in normal Purkinje fibres. Mechanism of action. The National Average Drug Acquisition Cost . Potassium is an essential nutrient, like [] and [].It was identified as a shortfall nutrient by the 2015-2020 Advisory Committee of Dietary Guidelines for Americans. In general, dilute each 20 mEq potassium in at least 90 mL water or juice and allowed to completely before administration. The safety and effectiveness of . To date, seven subtypes of inward rectifier potassium channels (Kir1-Kir7) and several subtypes of delayed rectifier potassium channels (Kv7, Kv11, mink, MiRP, etc.) MIMS Class Electrolytes ATC Classification A12BA01 - potassium chloride ; Belongs to the class of potassium-containing preparations. When the human skin comes in contact with the activated chemical, it can burn or ulcerate the skin. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away. Do not share your drugs with others and do not take anyone else's drugs. The protein of the transporter gene, symbolized as SLC12A1 in human and mouse, is structurally related (64% amino . Commonly used as an additive for low sodium salt and mineral water. It has the shape of small white or red crystals and large white or red particles. In very low birth weight infants, excessive or rapid administration of Dextrose 5%, Sodium Chloride 0.45% and Potassium Chloride 20 mEq (Dextrose) injection may result in increased serum osmolality and possible intracerebral hemorrhage. On August 19, 2015, the FDA approved a second 505 (b) (2) drug application for potassium chloride oral solution, a potassium replacement therapy typically for patients taking potassium-depleting diuretics. Potassium chloride is a medicine used to prevent or treat low potassium levels in the body. 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